PulmoSal™ 7% (pH+)

Bio-Balanced™ Hypertonic Saline

 Indication.  For the induction of sputum
where sputum production is indicated.

Bio-Balanced.  PulmoSal 7% (pH+) is
formulated to match the natural physiologic
pH of the airway surface liquid (ASL) @ ±7.4.

Notice (June 1, 2016:  McKesson has changed its ordering part number for
PulmoSal 7% (pH+) from 2043438 to 3543535.  Please update your records.

Unique, Non-Acidic Inhalation Solution  

  • Only FDA-cleared sodium chloride solution for inhalation that is buffered with sodium bicarbonate to a pH of 7.4.
  • Other sodium chloride inhalation solutions are formulated with a pH of 4.5 to 7.0, clearly acidic.
  • Pseudomonas aeruginosa has an affinity to colonize in an acidic pH of ~6.0.
  • PulmoSal 7% (pH+), with a pH of 7.4,”does not add acidity to the ASL.



These data show approximately 5 log decrease in bacterial density in the pH 7.4 solution compared with approximately 2 log decrease in the pH 5.86 and pH 6.6 solutions at 24 hours. The density difference between solutions is even more dramatic at 8 and 12 hours. These results suggest that a clinical trial designed to determine if increasing the pH of 7% HS reduces microbial density may be warranted. Given the dosing frequency of 7% HS in CF, these findings suggest that the use of physiologic pH+ solution could have a marked impact on bacterial density in CF sputum.1

The Complete Pulmonary Hygiene Triad
Now from Westmed 

PulmoSal 7% (pH+) is a component of the Complete Pulmonary Hygiene Triad from Westmed:  3 innovative technologies and solutions to promote and maintain airway clearance in a variety of pulmonary and neuromuscular conditions affecting secretion management.

Download the Complete Pulmonary Hygiene Triad Pamphlet for Patients

Visit the Circulaire II Page                Visit the Vibralung Site

Download the PulmoSal 7% (pH+) brochure
Ordering Information
PulmoSal Order Table (June 2016)
60 x 4 mL unit-dose vials per carton

Notice (June 1, 2016:  McKesson Pharmaceuticals has changed its ordering part number
for PulmoSal 7% (pH+) from 2043438 to 3543535.  Please update your records.

Technical and Educational Resources


1.  Burns JL, Griffith A.  pH-dependent differential Pseudomonas aeruginosa killing in CF sputum incubated with hypertonic saline solutions.  Peds Pulmonol 2014.  49;S38: 351.   2014 NACFC Abstract     2014 NACFC Poster

Additional Reading on Airway Surface Liquid pH

Ng AW, et al.  Innate host defense of the lung: Effects of lung-lining fluid pH.  Lung 2004.  182:5 (Nov): 297-317.

Pezzulo AA, et al.  Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.  Nature 2012. 487; July: 109-113.

MSDS (Material Safety Data Sheet)

Sodium Chloride Solution for Inhalation with pH of 7.4 for concentration 7%, NDC 50190-740-60.   PDF, 279 Kb

Frequently Asked Questions